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. 2021 Jan 12;11:788. doi: 10.1038/s41598-020-80876-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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In vitro cell viability tests on various human cancer cell lines and a normal cell line. All viabilities are represented as percentages with respect to the control (untreated cells, taken as 100% survival). The MTT assay was performed to obtain RDM-B (BV10) cytotoxicity and toxicity profiles (A), cell-killing efficacies of CDDP and its combination with BV10 in cervical cancer HeLa cells (B) and ME-180 cells (C), lung cancer A549 cells (D), ovarian cancer NIH:OVCAR-3 cells (E), and normal cells (F), in which error bars represent the standard deviation of data obtained in each group. All MTT experiments were performed at 24 h post-treatment. The clonogenic assay was performed in A549 (G), ME-180 (H), NIH:OVCAR-3 (I), and HeLa (J) cells for 2 h treatment with CDDP and its combination with BV10, in which error bars represent the standard error of the mean (s.e.m.) of data obtained in each group. The p values reported on the graph were obtained from unpaired two-tail student t tests: ****, p < 0.0001; ***, p < 0.001; **, p < 0.01; *, p < 0.05; n.s., nonsignificant (p ≥ 0.05).