Table 1.

Rare event logistic regression of interventional effect on efficacy and safety among groups

	n (%)	n1 (%)	n2 (%)	OR	95% CI	P value
Interventional effect on clinical improvement
Mild stroke	283 (32.7)	65 (63.1)	496 (66.9)	0.81	0.51 to 1.28	0.3554
Moderate stroke	704 (39.5)	122 (58.1)	899 (59.3)	1.23	0.71 to 2.13	0.4551
Severe stroke	245 (30.4)	59 (64.8)	416 (66.1)	1.12	0.58 to 2.17	0.7278
Interventional effect on sICH
Mild stroke	17 (1.97)	4 (3.77)	13 (1.71)	2.71	0.80 to 7.69	0.1026
Moderate stroke	59 (3.31)	2 (0.94)	57 (3.63)	0.13	0.02 to 0.68	0.0159*
Severe stroke	71 (8.80)	14 (13.3)	57 (8.12)	0.65	0.19 to 2.55	0.5180

Groups: mild: NIHSS 0–4; moderate: NIHSS 5–14; severe: NIHSS ≥15.

*P<0.05. Compared with those treated with standard dosage, patients treated with lower dosage of tPA have significantly less risk of sICH.

n1, number in low dose group; n2, number in standard dose group; n, total sample size in each group; NIHSS, National Institutes of Health Stroke Scale; sICH, symptomatic intracranial haemorrhage; tPA, tissue plasminogen activator.