Table 3.

Differential intracellular metabolites between RA-CH-1 and RA-CH-2 groups.

Metabolites	Mean ± SD		VIP	p valuea	log2(FC)b
	RA-CH-1	RA-CH-2
Adenine	88.54 ± 19.43	110.03 ± 22.20	1.06	*	0.31
Adenosine	77.82 ± 17.26	338.12 ± 154.50	1.72	***	2.12
Aspartic acid	525.50 ± 106.35	1021.23 ± 264.38	1.74	***	0.96
Citramalic acid	51.22 ± 19.92	15.09 ± 8.07	1.72	***	− 1.76
Cytosine	22.21 ± 6.94	40.20 ± 13.32	1.47	*	0.86
Fructose	1023.72 ± 907.79	2599.22 ± 467.83	1.66	**	1.34
Fructose-6-phosphate	66.38 ± 29.12	25.60 ± 8.21	1.56	**	− 1.37
Galactose	176.68 ± 144.09	432.91 ± 76.62	1.68	**	1.29
Glucopyranose	350.48 ± 68.97	1858.82 ± 1062.14	1.60	***	2.41
Glucose	194.45 ± 168.22	488.47 ± 84.99	1.67	**	1.33
Glucose-6-phosphate	86.96 ± 22.83	24.40 ± 6.82	1.96	***	− 1.83
Glyceric acid-3-phosphate	53.68 ± 33.34	92.06 ± 25.08	1.25	*	0.78
Guanine	233.34 ± 49.57	83.22 ± 14.72	1.99	***	− 1.49
Guanosine	39.83 ± 9.77	165.73 ± 74.72	1.72	***	2.06
Lactic acid	494.68 ± 92.30	375.54 ± 128.45	1.08	*	− 0.40
Malic acid	26.19 ± 9.95	70.79 ± 22.97	1.76	**	1.43
Nonanoic acid	10.33 ± 2.54	14.19 ± 3.16	1.28	*	0.46
Ornithine	935.73 ± 335.20	1984.35 ± 281.19	1.92	***	1.08
Pyruvic acid	227.56 ± 70.23	152.76 ± 21.49	1.34	*	− 0.57
Serine	939.73 ± 223.20	1287.73 ± 278.92	1.30	*	0.45
Thymine	42.06 ± 11.39	60.38 ± 11.39	1.43	*	0.52
Uracil	285.50 ± 94.70	488.10 ± 109.47	1.59	**	0.77
Urea	616.48 ± 729.53	72.77 ± 56.60	1.07	**	− 3.08
Uridine	135.27 ± 14.28	225.75 ± 43.44	1.82	***	0.74

^a*p < 0.05; **p < 0.01; ***p < 0.001.

^bFC: fold change in RA-CH-2/RA-CH-1.