Table 2.
Potential transcription factors binding to the proximal and/or minimal promoter regions of NME1 promoter.
| Transcription factor | Potential binding site | Role in breast cancer metastasis | Expression in aggressive breast cancer |
|---|---|---|---|
| CTCF | M1 | Suppressor32 | Downregulation32 |
| EGR1 | M4, M10, M11 | Suppressor33 | Downregulation34 |
| ELF1 | M6 | Suppressor35 | Downregulation36 |
| EGR2 | M10, M11 | ND | Upregulation37 |
| EGR3 | M10, M11 | ND | ND |
| ELF5 | M6 | Suppressor38 | Downregulation39 |
| GABPA | M6 | ND | Downregulation36 |
| KLF2 | M4 | Suppressor40 | No correlation40 |
| KLF6 | M4 | ND | No correlation41 |
| OLF1 | M8 | ND | ND |
| PU.1 | M9 | ND | No correlation42 |
Transcription factors predicted to bind to significant binding sites according to mutagenesis studies (Fig. 2) are shown. ELF1, ELF5, and GABPA, represent the ETS family of transcription factors. The potential role in breast cancer metastasis and expression in aggressive breast cancer are also cited.
ND not determined, NA not available.