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. 2021 Jan 12;11:496. doi: 10.1038/s41598-020-79774-1

Figure 7.

Figure 7

(A) NF-κB activation in LPS-challenged THP-1 Lucia cells in the presence of compounds 1, 4, 6–10 for 24 h. Incubation with LPS corresponds to maximum NF-κB response, with molecules capable of inhibiting the activation of the transcription factor (6 and 9) presenting lower activity values. (B) Experimental model used for the assessment of NF-κB in THP-1 luciferase-transfected cells. (C) COX-2, IL-6, TNF-α and IL-1β mRNA expression in THP-1 cells. mRNA expression was determined by qPCR after normalization with GAPDH reference gene. Horizontal dashed red line corresponds to the basal expression of the gene in untreated cells. *p < 0.05; **p < 0.01; ***p < 0.001.