Table 2.
Carrier frequencies of HLA-DRB1 in patients with MS and NMOSD and in healthy controls.
| DRB1 | MS (n = 528) | NMOSD (n = 165) | HCs (n = 394) | MS vs. HCs | NMOSD vs. HCs | ||||
|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | puncorr | pcorr | OR (95% CI) | puncorr | pcorr | ||||
| 01:01 | 29 (5.5) | 25 (15.2) | 53 (13.5) | 0.38 (0.23–0.60) | < 0.001 | 0.001 | 1.15 (0.69–1.92) | NS | NS |
| 03:01 | 1 (0.2) | 1 (0.6) | 0 | – | NS | NS | – | NS | NS |
| 04:01 | 9 (1.7) | 6 (3.6) | 9 (2.3) | 0.74 (0.29–1.89) | NS | NS | 1.61 (0.57–4.61) | NS | NS |
| 04:03 | 46 (8.7) | 5 (3.0) | 22 (5.6) | 1.61 (0.95–2.73) | NS | NS | 0.53 (0.20–1.42) | NS | NS |
| 04:04 | 4 (0.8) | 0 | 2 (0.5) | 1.50 (0.27–8.21) | NS | NS | – | NS | NS |
| 04:05 | 214 (40.5) | 26 (15.8) | 100 (25.4) | 2.00 (1.51–2.67) | < 0.001 | < 0.001 | 0.55 (0.34–0.89) | 0.014 | NS |
| 04:06 | 53 (10.0) | 5 (3.0) | 26 (6.6) | 1.58 (0.97–2.57) | NS | NS | 0.44 (0.17–1.17) | NS | NS |
| 04:07 | 7 (1.3) | 0 | 4 (1.0) | 1.31 (0.38–4.51) | NS | NS | – | NS | NS |
| 04:10 | 29 (5.5) | 6 (3.6) | 8 (2.0) | 2.80 (1.27–6.20) | 0.010 | NS | 1.82 (0.62–5.33) | NS | NS |
| 07:01 | 1 (0.2) | 2 (1.2) | 2 (0.5) | 0.37 (0.03–4.12) | NS | NS | 2.40 (0.34–17.22) | NS | NS |
| 08:01 | 0 | 0 | 1 (0.3) | – | NS | NS | – | NS | NS |
| 08:02 | 54 (10.2) | 30 (18.2) | 29 (7.4) | 1.43 (0.89–2.30) | NS | NS | 2.80 (1.62–4.83) | < 0.001 | 0.008 |
| 08:03 | 85 (16.1) | 22 (13.3) | 56 (14.2) | 1.16 (0.80–1.67) | NS | NS | 0.93 (0.55–1.58) | NS | NS |
| 08:09 | 1 (0.2) | 0 | 0 | – | NS | NS | NA | NA | NA |
| 09:01 | 76 (14.4) | 15 (9.1) | 104 (26.4) | 0.47 (0.34–0.65) | < 0.001 | < 0.001 | 0.28 (0.16–0.50) | < 0.001 | < 0.001 |
| 10:01 | 5 (1.0) | 3 (1.8) | 2 (0.5) | 1.87 (0.36–9.71) | NS | NS | 3.63 (0.60–21.93) | NS | NS |
| 11:01 | 16 (3.0) | 10 (6.1) | 19 (4.8) | 0.62 (0.31–1.22) | NS | NS | 1.27 (0.58–2.80) | NS | NS |
| 12:01 | 25 (4.7) | 16 (9.7) | 38 (9.6) | 0.47 (0.28–0.79) | 0.005 | NS | 1.01 (0.54–1.86) | NS | NS |
| 12:02 | 8 (1.5) | 13 (7.9) | 15 (3.8) | 0.39 (0.16–0.93) | 0.033 | NS | 2.16 (1.00–4.65) | NS (0.055) | NS |
| 13:01 | 1 (0.2) | 0 | 2 (0.5) | 0.37 (0.03–4.12) | NS | NS | – | NS | NS |
| 13:02 | 15 (2.8) | 21 (12.7) | 46 (11.7) | 0.22 (0.12–0.40) | < 0.001 | < 0.001 | 1.10 (0.64–1.92) | NS | NS |
| 13:03 | 0 | 1 (0.6) | 0 | NA | NA | NA | – | NS | NS |
| 13:07 | 1 (0.2) | 0 | 1 (0.3) | 0.75 (0.05–11.96) | NS | NS | – | NS | NS |
| 14:02 | 0 | 0 | 1 (0.3) | – | NS | NS | – | NS | NS |
| 14:03 | 18 (3.4) | 7 (4.2) | 14 (3.6) | 0.96 (0.47–1.95) | NS | NS | 1.20 (0.48–3.04) | NS | NS |
| 14:05 | 26 (4.9) | 13 (7.9) | 15 (3.8) | 1.31 (0.68–2.51) | NS | NS | 2.16 (1.00–4.65) | NS (0.055) | NS |
| 14:06 | 8 (1.5) | 4 (2.4) | 6 (1.5) | 0.99 (0.34–2.89) | NS | NS | 1.61 (0.45–5.77) | NS | NS |
| 14:07 | 0 | 0 | 2 (0.5) | – | NS | NS | – | NS | NS |
| 14:54 | 20 (3.8) | 14 (8.5) | 28 (7.1) | 0.51 (0.29–0.93) | 0.035 | NS | 1.21 (0.62–2.37) | NS | NS |
| 15:01 | 179 (33.9) | 33 (20.0) | 67 (17.0) | 2.50 (1.82–3.44) | < 0.001 | < 0.001 | 1.22 (0.77–1.94) | NS | NS |
| 15:02 | 76 (14.4) | 31 (18.8) | 83 (21.1) | 0.63 (0.45–0.89) | 0.010 | NS | 0.87 (0.55–1.37) | NS | NS |
| 16:02 | 8 (1.5) | 6 (3.6) | 4 (1.0) | 1.50 (0.45–5.02) | NS | NS | 3.68 (1.02–13.21) | NS (0.072) | NS |
Bold values indicate significant differences.
Values are numbers (%).
CI confidence interval, HC healthy control, MS multiple sclerosis, NA not applicable, NS not significant, OR odds ratio, pcorr corrected p value, puncorr uncorrected p value.