Table 3.
Carrier frequencies of HLA-DPB1 in patients with MS and NMOSD and in healthy controls.
| DPB1 | MS (n = 528) | NMOSD (n = 165) | HCs (n = 394) | MS vs. HCs | NMOSD vs. HCs | ||||
|---|---|---|---|---|---|---|---|---|---|
| OR (95%CI) | puncorr | pcorr | OR (95%CI) | puncorr | pcorr | ||||
| 01:01 | 1 (0.2) | 0 | 0 | – | NS | NS | NA | NA | NA |
| 02:01 | 197 (37.3) | 57 (34.6) | 148 (37.6) | 0.99 (0.76–1.30) | NS | NS | 0.88 (0.60–1.28) | NS | NS |
| 02:02 | 28 (5.3) | 15 (9.1) | 21 (5.3) | 0.99 (0.56–1.78) | NS | NS | 1.78 (0.89–3.54) | NS | NS |
| 03:01 | 72 (13.6) | 6 (3.6) | 25 (6.4) | 2.33 (1.45–3.75) | < 0.001 | 0.006 | 0.56 (0.22–1.38) | NS | NS |
| 04:01 | 18 (3.4) | 19 (11.5) | 36 (9.1) | 0.35 (0.20–0.63) | < 0.001 | 0.006 | 1.29 (0.72–2.33) | NS | NS |
| 04:02 | 86 (16.3) | 31 (18.8) | 73 (18.5) | 0.86 (0.61–1.21) | NS | NS | 1.02 (0.64–1.62) | NS | NS |
| 05:01 | 367 (69.5) | 135 (81.8) | 254 (64.5) | 1.26 (0.95–1.66) | NS | NS | 2.48 (1.59–3.88) | < 0.001 | < 0.001 |
| 06:01 | 5 (1.0) | 2 (1.2) | 8 (2.0) | 0.46 (0.15–1.42) | NS | NS | 0.59 (0.12–2.82) | NS | NS |
| 09:01 | 73 (13.8) | 27 (16.4) | 70 (17.8) | 0.74 (0.52–1.06) | NS | NS | 0.91 (0.56–1.47) | NS | NS |
| 13:01 | 23 (4.4) | 4 (2.4) | 17 (4.3) | 1.01 (0.53–1.92) | NS | NS | 0.55 (0.18–1.66) | NS | NS |
| 14:01 | 23 (4.4) | 2 (1.2) | 11 (2.8) | 1.59 (0.76–3.29) | NS | NS | 0.43 (0.09–1.95) | NS | NS |
| 17:01 | 1 (0.2) | 1 (0.6) | 0 | – | NS | NS | – | NS | NS |
| 19:01 | 7 (1.3) | 1 (0.6) | 4 (1.0) | 1.31 (0.38–4.51) | NS | NS | 0.59 (0.07–5.36) | NS | NS |
| 22:01 | 0 | 0 | 1 (0.3) | – | NS | NS | – | NS | NS |
| 25:01 | 1 (0.2) | 0 | 0 | – | NS | NS | NA | NA | NA |
| 36:01 | 3 (0.6) | 0 | 0 | – | NS | NS | NA | NA | NA |
| 38:01 | 1 (0.2) | 0 | 0 | – | NS | NS | NA | NA | NA |
| 41:01 | 0 | 2 (1.2) | 2 (0.5) | – | NS | NS | 2.40 (0.34–17.22) | NS | NS |
Bold values indicate significant differences.
Values are numbers (%).
CI confidence interval, HC healthy control, MS multiple sclerosis, NA not applicable, NS not significant, OR odds ratio, pcorr corrected p value, puncorr uncorrected p value.