Table 8.

Clinical and genetic factors associated with EDSS scores in RRMS.

EDSS score (ordinal scale)	Univariable		Multivariable
	Std β	p	Std β	p
Sex [female/male]	0.004	0.931	− 0.051	0.296
Age at onset (y)	0.090	0.060	0.218	< 0.001
Disease duration (y)	0.245	< 0.001	0.137	0.016
Number of relapses	0.307	< 0.001	0.281	< 0.001
CSF IgG abnormality [+/−]	0.052	0.321	0.076	0.135
any DMD [treated/non-treated]	0.061	0.202	0.069	0.165
HLA-DRB1*04:05 [+/−]	− 0.005	0.916	0.028	0.589
HLA-DRB1*15:01 [+/−]	0.076	0.111	0.106	0.037

Bold values indicate significant correlations.

CSF cerebrospinal fluid, DMD disease modifying drug, EDSS expanded disability status scale, RRMS relapsing–remitting multiple sclerosis, Std standardized, y years.