Table 2.
Platelet progenitors as sources for ex vivo production
| Progenitor | Origin | Collection | Amount in source | Source availability | Ethical issues |
|---|---|---|---|---|---|
| Megakaryocyte | Bone marrow | Invasive | Few | (N.C.) | (N.C.) |
| Hematopoietic stem cell | Cord blood | Non-invasive | Low | Donation-dependent (Limited) | (N.C.) |
| Embryonic stem cell (ESC) | Established from embryo | Non-invasive | Expandable | Donation-dependent (Very limited) | High |
| Induced pluripotent stem cell (iPSC) | Established from somatic cells | Minimally invasive | Expandable | Anyone | Few |
Bold indicate disadvantages; italics indicate advantages
N.C.: not considered