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. 2021 Jan 12;11:803. doi: 10.1038/s41598-020-80378-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Enzymatically derived oxysterols modulate iPSC derived human MN survival. (a) 24S-OHC improves MN viability at low concentrations, but diminishes it at high concentrations as assessed by the cell titer glow (CTG) and lactate dehydrogenase (LDH) assays. (b) 25-OHC reduces MN survival at 30 and 100 mM as assessed by the LDH assay. (c) 27-OHC adversely affects MN viability at 100 mM as assessed by the CTG assay. All comparisons made to vehicle controls (****p = 0.0001, ***p = 0.001, **p = 0.01, and *p = 0.05). Error bars represent ± SEM.