Figure 2.

Composite Manhattan plot showing results across 31 facial modules. Manhattan plot showing the position of genes on the x axis and MultiSKAT p-values on the y axis. A total of 31 points are plotted for each gene, representing their p-values in each of the 31 modules. The red horizontal line indicates the significance threshold (3.3 × 10^–7). The associated facial modules and the corresponding p-value for each gene that surpassed the threshold (marked as green dots) are shown above the Manhattan plot. The numbers to the bottom left of the facial images indicate the module identifiers in Fig. 1.