Table 3.

Reactome pathway enrichment analysis results for protein Lag 1 aggregate results for $\text{TF}\mathrm{\Delta }$ and TFD (top 20 pathways based on FDR for each time frame shown).

Reactome pathway	Matched IDs	p value	FDR
A. Total saliva protein: TF$\mathrm{\Delta }$
Neutrophil degranulation	96	$1.1\times {10}^{-16}$	$6.8\times {10}^{-14}$
Innate immune system	135	$1.1\times {10}^{-16}$	$6.8\times {10}^{-14}$
Immune system	158	$1.4\times {10}^{-15}$	$5.9\times {10}^{-13}$
Signaling by ROBO receptors	34	$1.2\times {10}^{-13}$	$3.8\times {10}^{-11}$
Regulation of expression of SLITs and ROBOs	29	$9.5\times {10}^{-13}$	$2.3\times {10}^{-10}$
Eukaryotic translation elongation	22	$1.7\times {10}^{-12}$	$3.5\times {10}^{-10}$
Cellular responses to stress	58	$3.3\times {10}^{-12}$	$5.7\times {10}^{-10}$
Cellular responses to external stimuli	58	$9.0\times {10}^{-12}$	$1.4\times {10}^{-9}$
Peptide chain elongation	20	$3.8\times {10}^{-11}$	$5.2\times {10}^{-9}$
Nonsense-mediated decay (NMD)	22	$6.8\times {10}^{-11}$	$7.5\times {10}^{-9}$
Nonsense mediated decay (NMD) enhanced by the Exon Junction Complex (EJC)	22	$6.8\times {10}^{-11}$	$7.5\times {10}^{-9}$
Nonsense mediated decay (NMD) independent of the exon junction complex (EJC)	20	$7.7\times {10}^{-11}$	$7.8\times {10}^{-9}$
Eukaryotic translation termination	20	$1.8\times {10}^{-10}$	$1.7\times {10}^{-8}$
SRP-dependent cotranslational protein targeting to membrane	21	$2.0\times {10}^{-10}$	$1.8\times {10}^{-8}$
Viral mRNA translation	20	$6.1\times {10}^{-10}$	$4.9\times {10}^{-8}$
Formation of a pool of free 40S subunits	19	$1.2\times {10}^{-9}$	$8.8\times {10}^{-8}$
Platelet degranulation	21	$2.4\times {10}^{-9}$	$1.7\times {10}^{-7}$
Selenocysteine synthesis	19	$3.2\times {10}^{-9}$	$2.2\times {10}^{-7}$
Regulation of insulin-like growth factor (IGF) transport and uptake by insulin-like growth factor binding proteins (IGFBPs)	20	$3.7\times {10}^{-9}$	$2.4\times {10}^{-7}$
Response of EIF2AK4 (GCN2) to amino acid deficiency	19	$4.3\times {10}^{-9}$	$2.6\times {10}^{-7}$
B. Total saliva protein: TFD
Eukaryotic translation elongation	6	$3.5\times {10}^{-7}$	$1.6\times {10}^{-4}$
Nonsense-mediated decay (NMD)	6	$1.1\times {10}^{-6}$	$1.6\times {10}^{-4}$
Nonsense mediated decay (NMD) enhanced by the exon junction complex (EJC)	6	$1.1\times {10}^{-6}$	$1.6\times {10}^{-4}$
Signaling by ROBO receptors	7	$3.2\times {10}^{-6}$	$2.9\times {10}^{-4}$
Translation	8	$3.2\times {10}^{-6}$	$2.9\times {10}^{-4}$
Peptide chain elongation	5	$6.9\times {10}^{-6}$	$4.7\times {10}^{-4}$
Nonsense mediated decay (NMD) independent of the exon junction complex (EJC)	5	$8.3\times {10}^{-6}$	$4.7\times {10}^{-4}$
Regulation of expression of SLITs and ROBOs	6	$1.0\times {10}^{-5}$	$4.7\times {10}^{-4}$
Formation of a pool of free 40S subunits	5	$1.1\times {10}^{-5}$	$4.7\times {10}^{-4}$
Eukaryotic translation termination	5	$1.1\times {10}^{-5}$	$4.7\times {10}^{-4}$
Selenocysteine synthesis	5	$1.4\times {10}^{-5}$	$4.9\times {10}^{-4}$
Viral mRNA translation	5	$1.5\times {10}^{-5}$	$4.9\times {10}^{-4}$
Interleukin-6 signaling	3	$1.5\times {10}^{-5}$	$4.9\times {10}^{-4}$
Response of EIF2AK4 (GCN2) to amino acid deficiency	5	$1.6\times {10}^{-5}$	$4.9\times {10}^{-4}$
SRP-dependent cotranslational protein targeting to membrane	5	$1.8\times {10}^{-5}$	$4.9\times {10}^{-4}$
GTP hydrolysis and joining of the 60S ribosomal subunit	5	$1.9\times {10}^{-5}$	$4.9\times {10}^{-4}$
L13a-mediated translational silencing of ceruloplasmin expression	5	$1.9\times {10}^{-5}$	$4.9\times {10}^{-4}$
Eukaryotic translation initiation	5	$2.8\times {10}^{-5}$	$6.4\times {10}^{-4}$
Cap-dependent translation initiation	5	$2.8\times {10}^{-5}$	$6.4\times {10}^{-4}$
Interleukin 6-family signaling	3	$8.0\times {10}^{-5}$	$1.8\times {10}^{-3}$