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VTI-1002 gel treatment inhibits skin fragility in BP murine model 48 h after the BP-IgG injection. Skin fragility in vehicle or VTI-1002 gel-treated mice was tested for Nikolsky’s sign by gently rubbing their flanks three times.
| Treatment | Skin detachment on either side of flanks | Skin detachment on both sides of flanks |
|---|---|---|
| Vehicle gel application | 9/9 | 7/9 |
| VTI-1002 gel application | 3/9 | 1/9 |
