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Mechanisms underlying glycolysis-induced drug resistance. Four basic mechanisms underlying glycolysis-induced drug resistance are depicted: inhibition of apoptosis, induction of EMT, induction of autophagy, inhibition of drug influx and enhancement of drug efflux. Apoptosis can be inhibited through different mechanisms: repair of DNA damage, prevention of DNA damage, inhibition of components of the apoptotic machinery. EMT, epithelial-mesenchymal transition.
