Table 5:

Scenario analysis showing the impact of disease burden on the ICER from a Public Healthcare Provider and Societal Perspective in South Africa.

	Public Healthcare Provider Perspective ICER (2018 US$)		Societal Perspective ICER (2018 US$)
	Base case analysis	Scenario analysis*	Base case analysis	Scenario analysis*
Pregnant women	2 010	11 015	Dominant	8 362
PLWHA	1 749	11 361	Dominant	8 012
Persons with UMC	2 618	11 541	Dominant	8 621
Persons aged ≥ 65 years	2 090	15 888	2 034	15 801
Children 6–59 months	7 490	23 620	5 267	21 161

PLWHA: Persons living with HIV/AIDS

UMC: Underlying Medical Conditions

Base case analysis: Incremental Cost-Effectiveness Ratio (ICER) estimated using the broad case definition of influenza-associated illness which includes all respiratory, all circulatory, non-respiratory/non-circulatory influenza-associated illness

Scenario analysis: ICER estimated using the narrower case definition of influenza-associated illness which includes only ILI and SARI, a subset of all respiratory influenza-associated illness

^*Supplementary Figure 5 presents the results of the probabilistic sensitivity analyses for the narrower case definition scenario