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. 2021 Jan 12;12:315. doi: 10.1038/s41467-020-20614-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Metagene plots of H3K27me3 coverage at H2AK121ub/H3K27me3-marked genes in the different mutants. Left panel shows results using previously published data²⁸ and right panel using data generated in this work (see “Methods”). Bar plots indicate the percentage of genes displaying different levels of H3K27me3 marks relative to WT in each mutant. Box plots below metagene plots show average signal at gene body in the different genotypes. The median (middle line), upper and lower quartiles (boxes), and minimum and maximum values (whiskers) are indicated. P values of differences between WT and mutants according to one-sided Mann–Whitney–Wilcoxon test are also indicated. b Same as in a but for only-H3K27me3-marked genes. Box plots below metagene plots show average signal at gene body in the different genotypes. The median (middle line), upper and lower quartiles (boxes), and minimum and maximum values (whiskers) are indicated. P values of differences between WT and mutants according to one-sided Mann–Whitney–Wilcoxon test are indicated. c Metagene plots of H2AK121ub coverage at H2AK121ub/H3K27me3-marked genes in the different mutants. Left panel results using previously published data²⁸ and right panel using data generated in this work (see “Methods”). Bar plots indicate the percentage of genes displaying different levels of H2AK121ub marks relative to WT in each mutant. Box plots below metagene plots show average signal at gene body in the different genotypes. The median (middle line), upper and lower quartiles (boxes), and minimum and maximum values (whiskers) are indicated. P values of differences between WT and mutants according to one-sided Mann–Whitney–Wilcoxon test are indicated. d Same as in c but for only-H2AK121ub-marked genes. Box plots below metagene plots show average signal at gene body in the different genotypes. The median (middle line), upper and lower quartiles (boxes), and minimum and maximum values (whiskers) are indicated. P values of differences between WT and mutants according to one-sided Mann–Whitney–Wilcoxon test are indicated. In all cases (a–d), data were generated from n = 2 biological independent ChIP-seq samples. The list of only-H2AK121ub, H2AK121ub/H3K27me3, and only-H3K27me3 marked genes are provided as a Source Data file.