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. 2021 Jan 12;12:315. doi: 10.1038/s41467-020-20614-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Accessibility profiles around the TSS of non-PcG-marked active genes, only-H2AK121ub, H2AK121ub/H3K27m3, and only-H3K27me3 marked genes in WT (upper panels). Model proposed for the role of H2AK121ub and/or H3K27me3 marks in defining different chromatin states that control transcriptional responses to different degrees (bottom panels).