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. 2021 Jan 12;11:504. doi: 10.1038/s41598-020-79990-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Tissue-specific allelic expression is observed in selected PD-associated risk loci. Allelic expression analysis of (a) rs14235 in BCKDK, (b) rs708723 in RAB7L1, (c) rs951366 in NUCKS1, (d) rs58231213 in LZTS3, and (e) rs2270968 in MCCC1 was performed in samples from whole blood from PD patients and healthy controls. Heterozygous cDNA samples were measured with five replicates and normalized to the corresponding genomic DNA (gDNA) samples. Columns are presented as the normalized change in Ct between the two alleles (nΔCt). Error bars represent the standard error of the mean. Differences between each sample to the gDNA pool were tested with a Mann–Whitney U test and were considered statistically significant when P ≤ 0.05 as indicated by asterisks. Ct cycle threshold.