Table 2.
Allelic expression results for 12 Parkinson’s disease genome-wide associated genes in human brain samples.
| Transcribed SNP | Gene | Het. samples | Risk allele | Observed ASE | Overall P value |
|---|---|---|---|---|---|
| rs14235 | BCKDK | 43 | A | G>A | 1.1 × 10–15 |
| rs749671 | ZNF646 | 33 | A | G>A | 2.2 × 10–16 |
| rs199355 | GPNMB | 40 | G | A=G | 0.8 |
| rs708723 | RAB7L1 | 53 | T | C<T | 2.2 × 10–16 |
| rs951366 | NUCKS1 | 48 | C | C<T | 2.6 × 10–12 |
| rs76179989 | STK39 | 15 | G | T=G | 0.8 |
| rs58241213 | LZTS3 | 52 | G | A<G | 4.4 × 10–15 |
| rs4649383 | SIPA1L2 | 25 | T | T=C | 0.5 |
| rs28481699 | WDHD1 | 41 | A | A<T | 1.9 × 10–6 |
| rs2270968 | MCCC1 | 39 | T | G<T | 8.3 × 10–8 |
| rs34311866 | TMEM175 | 30 | C | C>T | 5.9 × 10–7 |
| rs34884217 | TMEM175 | 11 | A | A<C | 7.8 × 10–8 |
| rs2230288 | GBA | 10 | A | G>A | 5.0 × 10–5 |
The overall P value was calculated using a non-parametric Mann–Whitney U test comparing the allelic expression of all genomic DNA samples with all cDNA samples.
SNP single nucleotide polymorphism, Het heterozygous, ASE allele-specific expression.