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. 2021 Jan 12;11:528. doi: 10.1038/s41598-020-80165-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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T cell activation results in partitioning of genome topology. (A) Violin plots showing the distribution of TAD sizes in resting and activated T cells and B cells determined from summed libraries called with TADbit. Numbers in parenthesis depict the number of TADs called in each category. (B) Violin plots showing the distribution of the span of differential chromatin interactions (DIs) determined at 25 kbp resolution (FDR < 0.05) that are lost (decrease in logFC) or gained (increase in logFC) upon activation. Violin plots show median (horizontal line), interquartile range (boxes), values of the upper and lower quartiles (whiskers), outliers (circles) and kernel density estimation. Data for CD4⁺ and CD8⁺ T cells were merged as they showed a similar pattern. (C) Pie charts showing distribution of Loss and Gain chromatin interactions in TADs that become smaller in size (left) or remain unchanged/became larger in size (right) upon T cell activation. Statistical comparisons were made with the unpaired Wilcoxon test.