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. 2021 Jan 12;11:528. doi: 10.1038/s41598-020-80165-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Increased strength in TAD boundary and chromatin interactions upon T cell activation is associated with nucleosome occupancy and gene expression. Box plots showing the distribution of the average (A) chromatin accessibility (logCPM), (B) nucleosome occupancy (NucleoATAC occupancy score) and (C) expression of protein-coding genes (logCPM) across differential TAD boundaries strengthened and weakened following activation of CD4⁺ and CD8⁺ T cells. Shown are the median (central horizontal line), interquartile range (boxes), values of the upper and lower quartiles (whiskers), outliers beyond 1.5 IQR (circles). Statistical comparisons were made with unpaired Wilcoxon tests.