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. 2021 Jan 12;11:826. doi: 10.1038/s41598-020-80637-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Corticosterone effect alcohol-induced intestinal dysbiosis: a functional analysis. Adult mice were fed a liquid diet with (EF) or without (PF) ethanol for four weeks. In some groups, animals were injected with corticosterone (CORT) daily. Animals in other groups were injected with the vehicle. Analysis of data from 16S rRNA-sequencing of fecal samples from different groups of mice is presented. (A) Functional categories associated with taxonomic composition were analyzed from the phylogenetic investigation of bacterial communities by PICRUSt. Spearman’s correlation on the most abundant microbial metabolic pathways in different groups is presented. (B–D) Effects of alcohol and corticosterone on the abundance of microbial categories expressing ethanol metabolizing enzymes, alcohol dehydrogenase (B), aldehyde dehydrogenase (C), and acetyl CoA synthetase (D).