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. 2021 Jan 12;11:745. doi: 10.1038/s41598-020-80497-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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VEGFR2 inhibition causes regression of human blood vessels. (a) Schema for tumor transplantation into the cranial window and ramucirumab or isotype IgG treatment. b-d, VEGFR2 inhibition decreases human blood vessels. Representative images of huCD31-AF488-positive human blood vessels (huCD31, green) (b). Quantification of total human blood vessel length (c) and relative length (d) after ramucirumab (Ram) or isotype IgG (Isotype) treatment. (e–g): Transplanted tissues were sectioned for the analysis of human and mouse blood vessels. Representative images for the expression of human CD31 (huCD31, green), mouse CD31 (moCD31, red), and/or human nuclei (HuNu, blue) (e). Quantification of the total length of human (f) and mouse (g) blood vessels. Data are mean ± SD. (isotype IgG: n = 5, ramucirumab: n = 4). Welch´s t test was used to compare with isotype IgG-treated mice. *: p < 0.05. **: p < 0.01. n.s.: not significant.