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. 2021 Jan 6;63:103157. doi: 10.1016/j.ebiom.2020.103157

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© 2020 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 3 — Regional plots for significant associated loci in single variant analyses. (a) Chromosome 1 locus; (b) Chromosome 2 locus; (c) Chromosome 15 locus; (d) Chromosome 17 locus; (e) Chromosome 19 locus. Each point represents a SNV, plotted with their p-value (on a -log₁₀ scale) as a function of genomic position (NCBI build 38). The index variant is represented by the purple symbol. The color coding of all other SNPs indicates LD with the index variant in haplotypes inferred from the TOPMed data: red r²≥0.8; gold 0.6 ≤ r²<0.8; green 0.4 ≤ r²<0.6; cyan 0.2 ≤ r²<0.4; blue r²<0.2; gray r² unknown. The horizontal line represents the significance threshold.

Fig. 3 — Regional plots for significant associated loci in single variant analyses. (a) Chromosome 1 locus; (b) Chromosome 2 locus; (c) Chromosome 15 locus; (d) Chromosome 17 locus; (e) Chromosome 19 locus. Each point represents a SNV, plotted with their p-value (on a -log₁₀ scale) as a function of genomic position (NCBI build 38). The index variant is represented by the purple symbol. The color coding of all other SNPs indicates LD with the index variant in haplotypes inferred from the TOPMed data: red r²≥0.8; gold 0.6 ≤ r²<0.8; green 0.4 ≤ r²<0.6; cyan 0.2 ≤ r²<0.4; blue r²<0.2; gray r² unknown. The horizontal line represents the significance threshold.