Table 1.

Significant findings for single trait genome-wide association of eGFR.

Chr:position (hg38)	SNV/indel	Coded allele/Other	Minor allele		Beta (SE) (Coded allele)	p	Gene	Function
			Freq Count
1:56,690,933	rs180996919	C/G	0.0004	19	−14.56 (2.2)	6.1 × 10−11	PRKAA2	Intronic
2:171,363,037	rs116951054	A/C	0.0009	41	9.10 (1.55)	4.5 × 10−9	METTL8	Intronic
15:45,355,229*	rs2461702	G/A	0.49	23,170	−0.63 (0.10)	1.2 × 10−10	GATM	Intergenic
17:39,466,919*	rs71147340	C/CT	0.34	16,247	−0.57 (0.10)	3.3 × 10−9	CDK12	Intronic
19:3,799,817	rs539182790	G/GGT	0.0005	26	−9.69 (1.64)	3.4 × 10−9	MATK	Intronic

SNV, single nucleotide variant. Significance threshold 5.0 × 10⁻⁹; betas are eGFR change in ml/min/1.73 m² for each additional copy of the coded allele. Freq, frequency of coded allele.

^⁎Previously reported loci. Regulatory annotation for rs180996919 (DHS, H3K4me1 muscle) and rs116951054 (DHS, H3K4me1 kidney).