Table 1.
Detailed statistical analysis of trabecular and cortical bone loss between mice receiving a combined burn and skeletal muscle injury (Burn + CTX; model of severe injury) or muscle injury alone (CTX; lesser injury) measured by endpoint μCT analysis. * notes significance (P) less than 0.05, **p<0.01, ***p<0.001.
| 1 DPI |
3 DPI |
7 DPI |
28 DPI |
Analysis between 1 and 28 DPI |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CTX (N=5) | CTX ± Burn (N=7) | CTX (N=5) | CTX ± Burn (N=6) | CTX (N=3) | CTX ± Burn (N=6) | CTX (N=10) | CTX ± Burn (N=10) | CTX | CTX ± Burn | |
| %BV/TV | 13.3 ± 2.8 | 16.6 ± 2.2 | 16.8 ± 0.024 | 9.5 ± 2.1** | 11.9 ± 2.9 | 6.3 ± 1.2* | 15.3 ± 3.7 | 5.8 ± 1.0*** | ns, p=0.636 | ***, p<0.001 |
| Trabecular thickness (μm) | 27 ± 2 | 26 ± 3 | 31 ± 10 | 23 ± 3* | 27 ± 3 | 21 ± 2 | 30 ± 4 | 23 ± 1** | ns, p=0.723 | ns, p=0.622 |
| Trabecular space (μm) | 181 ± 37 | 197 ± 22 | 150 ± 26 | 225 ± 29** | 203 ± 31 | 319 ± 47* | 170 ± 34 | 376 ± 72*** | ns, p=0.998 | ***, p<0.001 |
| Trabecular number (1/mm) | 4.92 ± 0.72 | 4.54 ± 0.41 | 5.69 ± 0.99 | 4.06 ± 0.43* | 4.40 ± 0.57 | 2.98 ± 0.38* | 5.14 ± 0.88 | 2.57 ± 0.43*** | ns, p=0.988 | ***, p<0.002 |