Fig. 5.

Sex, age, and race/ethnicity differences in NRF2-regulated gene expression. Total liver RNA was isolated and purified from 247 normal human livers, and the expression of specific genes of interest was examined with specific primers via RT-qPCR compared with housekeeping genes (GAPDH and β-actin). (A) Sex, (B) age, and (C) race/ethnicity differences. The values of #NQO1 and #MTF-1 were multiplied by 10 to allow the expression to be visible. Data are mean ± S.E.M.; *significantly different from male, adult, and Caucasians, respectively, by one-way ANOVA at P < 0.05.