Fig. 6.

Positional variance diagram for the progression in ROMS patients as cognition declines (Model 3). The maximum-likelihood sequence of abnormality is shown on the y-axis (top to bottom). Colour intensity in each row indicates positional variance: the darker the colour, the higher the confidence of the event position across 1000 bootstraps (capped at 500 for visualisation). The biomarker ordering reflects the sequence obtained from fitting all subjects. EC = eigenvector centrality; EDSS: expanded disability status scale; FA: fractional anisotropy as a measure for microstructural WM tract changes; MUCCA: mean upper cervical cord area.