Table 1.
Summary of anticipated absolute differences comparing sodium-glucose cotransporter-2 inhibitor treatment with placebo treatment per 1000 patients with diabetes type 2 and with very low to very high cardiovascular risk, treated for five years
| Risk* | All cause mortality | Cardiovascular mortality | Non-fatal myocardial infarction | Non-fatal stroke | Kidney failure | Hospital admission for heart failure | Diabetic ketoacidosis | Genital infection | Body weight |
|---|---|---|---|---|---|---|---|---|---|
| Very low | 3 fewer (4 fewer to 2 fewer) ⊕⊕⊕ |
2 fewer (3 fewer to 1 fewer) ⊕⊕⊕ |
4 fewer (6 fewer to 1 fewer) ⊕⊕⊕ |
0 more (3 fewer to 4 more) ⊕⊕⊕ |
1 fewer (1 fewer to 0) ⊕⊕⊕ |
2 fewer (2 fewer to 1 fewer) ⊕⊕⊕ |
0 (1 fewer to 2 more) ⊕⊕⊕ |
143 more (119 more to 170 more) ⊕⊕⊕⊕ |
1.92 kg lower (2.23 lower to 1.62 lower) over 6 months ⊕⊕ |
| Low | 10 fewer (15 fewer to 6 fewer) ⊕⊕⊕⊕ |
7 fewer (11 fewer to 4 fewer) ⊕⊕⊕⊕ |
7 fewer (12 fewer to 2 fewer) ⊕⊕⊕⊕ |
1 more (6 fewer to 8 more) ⊕⊕⊕⊕ |
3 fewer (4 fewer to 1 fewer) ⊕⊕⊕⊕ |
9 fewer (11 fewer to 7 fewer) ⊕⊕⊕⊕ |
|||
| Moderate | 18 fewer (25 fewer to 10 fewer) ⊕⊕⊕⊕ |
12 fewer (18 fewer to 6 fewer) ⊕⊕⊕⊕ |
13 fewer (21 fewer to 3 fewer) ⊕⊕⊕⊕ |
1 more (11 fewer to 13 more) ⊕⊕⊕⊕ |
6 fewer (9 fewer to 2 fewer) ⊕⊕⊕⊕ |
23 fewer (28 fewer to 17 fewer) ⊕⊕⊕⊕ |
|||
| High | 26 fewer (36 fewer to 14 fewer) ⊕⊕⊕⊕ |
16 fewer (25 fewer to 8 fewer) ⊕⊕⊕⊕ |
14 fewer (23 fewer to 3 fewer) ⊕⊕⊕⊕ |
1 more (12 fewer to 15 more) ⊕⊕⊕⊕ |
25 fewer (37 fewer to 9 fewer) ⊕⊕⊕⊕ |
29 fewer (36 fewer to 22 fewer) ⊕⊕⊕⊕ |
|||
| Very high | 40 fewer (56 fewer to 21 fewer) ⊕⊕⊕⊕ |
24 fewer (36 fewer to 12 fewer) ⊕⊕⊕⊕ |
21 fewer (34 fewer to 5 fewer) ⊕⊕⊕⊕ |
2 more (17 fewer to 21 more) ⊕⊕⊕⊕ |
38 fewer (58 fewer to 14 fewer) ⊕⊕⊕⊕ |
58 fewer (73 fewer to 44 fewer) ⊕⊕⊕⊕ |
*
Risk categories represent the following patient populations: very low=no or less than three cardiovascular risk factors; low=three or more cardiovascular risk factors; moderate=cardiovascular disease; high=chronic kidney disease (reduced glomerular filtration rate or macroalbuminuria); very high=cardiovascular disease and chronic kidney disease.
Certainty of the evidence for each estimate is shown: high certainty ⊕⊕⊕⊕; moderate certainty ⊕⊕⊕; low certainty ⊕⊕; very low certainty ⊕.