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. 2021 Jan 9;27(1):134–144. doi: 10.1111/cns.13580

FIGURE 6.

FIGURE 6

Perampanel protects against TBI‐induced brain damage and neuroinflammation. (A) Perampanel decreases brain water content at 24 h after TBI. (B) Perampanel preserves neurological function at 72 h after TBI. (C and D) TUNEL staining (C) and quantification (D) show that perampanel inhibits neuronal apoptosis at 24 h after TBI. (E and F) Immunostaining (E) and quantification (F) show that perampanel inhibits the activation of microglial cells at 24 h after TBI. Scale bar, 50 μm. Error bars indicate SEM (n = 6). # p < 0.05 vs. Sham group. *p < 0.05 vs. TBI group