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Perampanel regulates BBB function via Sirt3 after TBI. (A) Perampanel preserves Sirt3 expression after TBI. (B) Transfection with Si‐Sirt3 decreases the expression of Sirt3 in vivo. (C) Perampanel decreases Evans blue content via Sirt3 after TBI. (D) The perampanel‐induced decrease in brain water content after TBI was prevented by Sirt3 knockdown. Scale bar, 50 μm. Error bars indicate SEM (n = 6). # p < 0.05 vs. Sham group. *p < 0.05 vs. TBI group. & p < 0.05
