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. 2021 Jan 12;12:338. doi: 10.1038/s41467-020-20565-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a mCA events and their co-occurring gene mutations. Events are colored by alteration types. Only genes that appear more than one time are shown. b Gene loci that exhibited recurrent double hits in cis. Zoom window shows the gene loci affected and the location of the gene mutations; “2” denotes two adjacent mutations in close proximity with each other. Centromere positions are marked in gray. Gene structures are displayed below. c Pairwise associations of co-mutations between specific mCAs and gene mutations. Associations with specific chromosomal alteration types are indicated by the position of the triangle (left: AMP, top: CNLOH, right: DEL, bottom: any). FDR-corrected significance values from pairwise Fisher’s exact tests are indicated by shapes of asterisks. Odds ratios are indicated by the transparency of red shading. The chromosomal location of genes are indicated by black squares. Gene labels are colored by functional groups. Source data are provided as a Source Data file.