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. 2021 Jan 12;12:289. doi: 10.1038/s41467-020-20449-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Bronchoalveolar lavage (BAL) IL6 levels from miR-146a knockout (KO, left panel) and wild-type (WT, right panel) mice subjected to ventilator-induced lung injury (VILI) following adoptive transfer of WT or miR-146a KO bone-marrow-derived macrophages (BMDMs). Data normally distributed, p = 0.0847 via two-tailed Student’s t-test comparing KO recipients, p = 0.0007 via two-tailed Student’s t-test comparing WT recipients. b BAL KC/CXCL1 levels from KO (left panel) and WT (right panel) mice subjected to VILI following adoptive transfer of WT or KO BMDMs. Data not normally distributed, p = 0.0006 via Mann–Whitney test. c Change in lung tissue elastance following 4 h VILI, normalized to baseline elastance prior to VILI. All data normally distributed, analyzed by two-tailed Student’s t-test. d Oxygen saturation throughout duration of VILI measured via pulse oximetry. e BAL protein levels from KO (left panel) and WT (right panel) mice subjected to VILI following adoptive transfer of WT or KO BMDMs. f miR-146a expression in BAL cell pellet RNA from KO (left panel) and WT (right panel) mice subjected to VILI following adoptive transfer of WT or KO BMDMs. Relative expression determined by ΔΔCt method, normalized to WT mice that received WT BMDMs. Data normally distributed, analyzed by two-tailed Student’s t-test; *p < 0.0001 compared to KO recipients that received KO BMDMs, **p = 0.0290 compared to WT recipients that received WT BMDMs. For all panels KO recipients: n = 14 KO BMDMs, n = 13 WT BMDMs. For WT recipients: n = 7 per group. Data are presented as mean ± SEM.