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. 2021 Jan 12;11:602. doi: 10.1038/s41598-020-80596-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Alanine-scanning mutants of Yodha (A) List of alanine-scanning mutants of Yodha. (B) Change in virucidal activity of alanine-scanning mutant peptides compared with Yodha peptide which was set as zero. T-test two tailed p-value (*) p = 0.021, (ns) Non significant p = 0.1553. (C) Each of the alanine scan mutants was tested for cytotoxicity test using human red blood cells. (D) Both, the L-enantiomer of Yodha (L-Yodha), and the D-enantiomer (D-Yodha) exhibited comparable anti-viral activity against ZIKV.