Skip to main content
. 2020 Jun 22;22(1):24–56. doi: 10.1021/acs.biomac.0c00663

Table 3. Overview of Dosage Forms Based on Thiolated Chitosans.

dosage form active pharmaceutical ingredient references
Used as Therapeutic Agent
eye drops chitosan–N-acetylcysteine (181, 182, 185, 194, 195)
  chitosan–cysteine (197)
 
Drug Delivery Systems
Oral Delivery
hydrogel leuprolide (158)
liposomes calcitonin (91)
docetaxel (75)
micelles paclitaxel (80)
microparticles acyclovir (198)
nanoemulsion curcumin (55)
nanoparticles amoxicillin (192)
cherry extract delivery (87)
docetaxel (63, 74, 146, 199)
fluorescein diacetate as model compound (82)
insulin (84, 200, 201)
low-molecular-weight heparin (160)
Map4k4 siRNA (38)
paromomycin (78)
sitagliptin (202)
TNF-α siRNA (31, 112)
polymer solution Rhodamine-123 as model P-gp substrate (203)
polymer tablets antide (151, 155)
calcitonin (204)
insulin (43, 205)
naproxen (86)
Rhodamine-123 as model P-gp substrate (203)
self-emulsifying drug delivery system insulin (206)
Ocular Delivery
nanoparticles curcumin (143, 144)
polymer solution dexamethasone (111)
Nasal Delivery
hydrogel containing proniosomes duloxetine (207)
microparticles insulin (208, 209)
paliperidone (210)
nanoparticles bovine serum albumin as model compound for vaccination (67)
galantamine (211)
insulin (156)
leuprolide (212)
pDNA encoding for green fluorescent protein (213)
selegiline (157)
theophylline (214)
tizanidine (215)
Buccal delivery
freeze-dried hydrogels bovine serum albumin as model macromolecular compound (216, 217)
insulin (218)
nanofiber mats Garcinia mangostana extract (128)
α-mangostin (219)
polymer films calcium fluoride (220)
fluconazole (221)
lignocaine (220)
risedronate (73)
polymer films containing nanoparticles insulin (28, 33)
polymer solution pituitarity adenlyate cyclase-activating polypeptide (222)
polymer tablets pituitarity adenlyate cyclase-activating polypeptide (159)
Vaginal Delivery
microparticles tenofovir (223)
nanofibers tenofovir (224)
nanoparticles tenofovir (225)
polymer tablets metronidazole (96)
Intravesical Delivery
microparticles fluorescein diacetate as model compound (226)
nanoparticles fluorescein diacetate as model compound (226)
gemcitabine (227)
Pulmonary Delivery
Nanoparticles calcitonin (76)
Transdermal Delivery
polymer film carvedilol (228)
microneedle patch tacrolimus (196)
Colonic Delivery
microcapsules probiotic bacteria (229)
Parenteral delivery
hydrogels bendamustine (136)
curcumin (191, 230, 231)
nanoparticles 5-fluorouracil (232)
curcumin (232)
meglumine antimoniate (172)
pDNA encoding for green fluorescent protein (34, 79)
TNF-α siRNA (112)
VEGF siRNA (233)