Figure 17.

(A) Schematic representation of the transformation of micelles to supramolecular fibers in the presence of cancer cells. When the micelles approaches the cell, where there is an elevated level of MMP-9, the micelles are hydrolyzed and the doxorubicin will be trapped in the fibrillar structures. These fibrillar structures will release doxorubicin in a sustained matter to the cancer cell, which will cause the cell to die. (B) Chemical structures of the MMP-9 responsive peptide amphiphile. Reprinted with permission from Kalafatovic, D.; Nobis, M.; Son, J.; Anderson, K. I.; Ulijn, R. V. MMP-9 Triggered Self-assembly of Doxorubicin Nanofiber Depots Halts Tumor Growth. Biomaterials2016, 98, 192–202,. Copyright 2016 Elsevier.