Table 2.

Scores on CAT, mMRC, and original questionnaire survey, and visual analog scale after using each inhaler

	Gly/Ind	Ume/Vil	Tio/Olo	P value
				Gly/Ind versus Ume/Vil	Gly/Ind versus Tio/Olo	Ume/Vil versus Tio/Olo
CAT	14.2 ± 8.5	14.6 ± 9.0	14.1 ± 8.6	0.9454	0.9975	0.9208
mMRC	1.86 ± 0.95	1.80 ± 1.01	1.89 ± 0.95	0.9359	0.9836	0.8617
Original questionnaire
① Hoarseness	0.39 ± 0.84	0.31 ± 0.67	0.28 ± 0.54	0.7473	0.5964	0.9681
② Discomfort or irritation of the throat	0.39 ± 0.62	0.51 ± 0.91	0.27 ± 0.51	0.6027	0.5273	0.1051
③ Cough immediately after inhalation	0.54 ± 0.69	0.56 ± 0.86	0.46 ± 0.75	0.9742	0.8495	0.7267
④ Aftertaste	0.31 ± 0.60	0.65 ± 0.83	0.23 ± 0.45	0.0059	0.7164	0.0004
⑤ Headache	0.10 ± 0.45	0.08 ± 0.41	0.10 ± 0.34	0.9764	1	0.9764
⑥ Palpitation	0.14 ± 0.35	0.20 ± 0.52	0.08 ± 0.33	0.692	0.692	0.2325
⑦ Tremor	0.06 ± 0.23	0.10 ± 0.34	0.08 ± 0.28	0.6597	0.8309	0.9547
⑧ Eye pain, bleariness	0.20 ± 0.52	0.34 ± 0.70	0.32 ± 0.63	0.3671	0.4436	0.9899
⑨ Thirst	0.59 ± 0.87	0.53 ± 0.84	0.46 ± 0.71	0.8633	0.622	0.9102
⑩ Constipation	0.32 ± 0.63	0.46 ± 0.77	0.30 ± 0.62	0.4303	0.9666	0.2981
⑪ Difficulty of urination	0.30 ± 0.54	0.31 ± 0.71	0.28 ± 0.68	0.9908	0.9908	0.9638
⑫ About shape, size or design	1.01 ± 0.62	1.42 ± 0.77	1.21 ± 0.75	0.0024	0.2323	0.1878
⑬ About inhaler operation and procedure	1.06 ± 0.63	1.23 ± 0.74	1.14 ± 0.68	0.3082	0.7435	0.7435
⑭ About actual feeling of being able to inhale	1.01 ± 0.73	1.45 ± 1.01	1.64 ± 0.90	0.0103	< 0.0001	0.3821
⑮ About actual effect	1.58 ± 0.80	1.80 ± 0.77	1.70 ± 0.74	0.1936	0.5919	0.7277
⑯ Overall evaluation	1.35 ± 0.79	1.70 ± 0.93	1.54 ± 0.73	0.0311	0.3836	0.4416
Visual Analog Scale (cm)	6.65 ± 2.21	6.09 ± 2.32	6.06 ± 2.10	0.2924	0.2514	0.9954

CAT, COPD Assessment Test; mMRC, modified Medical Research Council dyspnea questionnaire