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. 2021 Jan 12;12:54. doi: 10.1186/s13287-020-02088-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 10 — Microarray analysis of significantly regulated genes in the CS-exposed lung. a The bar chart represents the total number of DEG, downregulated and upregulated DEG with p < 0.05 and FC > 2.0, which are considered significantly regulated. b Heat map shows different DEG regulation in the CS group as compared to the naive, hUC-MSC-EVs, and hUC-MSCs groups. c PCA plot shows a cluster of samples (n = 2) in the naive, CS, hUC-MSC-EVs, and hUC-MSCs groups. d Volcano plots of differentially expressed genes obtained from the microarray analysis. The red dots represent upregulated DEG, while blue dots represent downregulated DEG. p value generated using t test. e Venn diagram shows overlapping DEG among CS, hUC-MSC-EVs, and hUC-MSCs. A total of 9888 DEG were overlapped in 3 groups, 1610 DEG were overlapped between CS and hUC-MSC-EVs, 4597 DEG were overlapped between CS and hUC-MSCs, and 1976 DEG were overlapped between hUC-MSC-EVs and hUC-MSCs