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. 2021 Jan 12;12:54. doi: 10.1186/s13287-020-02088-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Goblet cell counts for the assessment of mucus overproduction. Quantitative histological staining (a) and analysis (b) of goblet cells within the bronchi. A significant increase in goblet cells was observed after 12 weeks of CS exposure with no reduction following 2 weeks of self-healing (CSSH). Treatment of the CS groups with MSCs significantly reduced the number of goblet cells and no significant reduction in response to UCMSC-EVs and UCMSC-CM (*p < 0.05, **p < 0.001)