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. 2021 Jan 13;16:51. doi: 10.1186/s13018-020-02177-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — NGF-CS/HA-coating implants induced the growth of nerve fibers in the peri-implant tissues. a The number of nerve fiber was confirmed via DiI neural tracer in HA- and NGF-CS/HA-coating implant groups at 2, 4, and 8 weeks. Magnification, × 100; scale bar = 200 μm. b The expression of NF200 was monitored using IHC assay in HA- and NGF-CS/HA-coating implant groups at 2, 4, and 8 weeks. Magnification, × 400; scale bar = 100 μm. The arrows denote the longitudinal section of the nerve fibers. Two dogs with 16 implant teeth (8 teeth for HA coating and 8 teeth for NGF-CS/HA coating) at each time point