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. 2021 Jan 13;12:56. doi: 10.1186/s13287-020-02114-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Changes in echocardiographic parameters in the transplanted hearts after cold storage with a preservation solution supplemented by N-CdM and H-CdM. The representative echocardiographic pictures are taken from M-mode recordings. Cardiac function and left ventricular size, as measured by echocardiographic parameters: a left ventricular ejection fraction (LVEF; as a percentage), b left ventricular fractional shortening (LVFS; as a percentage), c left ventricular internal dimension at end-systole (LVIDs; in millimeters), d left ventricular internal dimension at end-diastole (LVIDd; in millimeters), e stroke volume (SV; in microliter), f heart rate (HR; in beat per minute), g cardiac output (CO; in milliliter per minute), and h representative echocardiographic images of the transplanted heart in three groups. N-CdM and H-CdM indicate normoxic- and hypoxic-conditioned medium, respectively. Data represent mean ± standard error of the mean. One-way ANOVA/Kruskal-Wallis was applied in statistical analysis. *p < 0.05 vs. vehicle, #p < 0.05 vs. N-CdM