Table 1.
Differentially secreted cytokines levels between hypoxic and normoxic CdM-BMSCs measured by antibody array
| Protein name | EntrezID | Hypoxic CdM mean ± SD | Normoxic CdM mean ± SD | Fold change hypoxic/normoxic | p value |
|---|---|---|---|---|---|
| Decorin | 29139 | 10,299.06 ± 2918.47 | 5285.78 ± 157.00 | 1.901 | 0.041 |
| CINC-2 | 171551 | 96,123.26 ± 9191.66 | 57,240.66 ± 10,395.19 | 1.692 | 0.008 |
| PDGF-AA | 25266 | 250,149.29 ± 24,866.75 | 153,260.81 ± 43,629.50 | 1.668 | 0.029 |
| Neuropilin-2 | 81527 | 5556.21 ± 880.88 | 3613.78 ± 309.85 | 1.529 | 0.023 |
| Activin A | 29200 | 10,671.66 ± 987.40 | 7238.02 ± 1275.96 | 1.486 | 0.021 |
| b-NGF | 310738 | 23,323.71 ± 2472.75 | 16,720.57 ± 1002.78 | 1.391 | 0.013 |
| IL-6 | 24498 | 661.95 ± 74.93 | 497.30 ± 33.82 | 1.327 | 0.026 |
| VEGF | 83785 | 246,817.39 ± 15,669.76 | 198,745.19 ± 16,099.43 | 1.243 | 0.021 |
| Flt-3 L | 103691134 | 915.92 ± 9.66 | 757.78 ± 22.63 | 1.209 | 0.0004 |
| IL-10 | 25325 | 1824.10 ± 59.43 | 2406.64 ± 264.84 | 0.761 | 0.021 |
| IL-13 | 116553 | 818.78 ± 205.59 | 1273.62 ± 57.60 | 0.630 | 0.021 |
| CINC-1 | 81503 | 12,568.68 ± 4510.34 | 24,729.04 ± 2903.48 | 0.488 | 0.017 |
Significantly altered proteins listed first with a p value for the fold change. Data represent mean ± standard deviation (SD) (n = 3/group). T test/Mann-Whitney was applied in statistical analysis
CdM conditioned medium, CdM-BMSCs conditioned medium-derived from bone marrow mesenchymal stem cells