Table 3.

Interview questions for patients

Examples of questions included in the participant interview

- What is your experience of having CRS? (when did it start, duration, symptoms, previous treatments)

- How did you first hear about the MACRO trial (first contact and impressions,

- What information were you given about the MACRO trial (including trial purpose, design, interventions, randomisation possible risks and side effects, follow-up)

- Check participant’s understanding of key areas (randomisation procedures, surgery, medication, placebo)

- Check whether participant felt their recruiter had a preferred treatment or whether interventions were presented in a balanced manner (equipoise)

- How did you feel about being invited to take part?

- What were your reasons for deciding whether (or not) to take part.

- Did you have any concerns or queries about the trial?

- How were these answered by the recruiter/research nurse?

- How did you find the experience of being recruited/screened for MACRO and were there any ways this could be improved for other patients in the future?

- Feedback on the participant information sheet and other written materials

- Feedback on any other ways to improve patients’ experience on the MACRO trial.