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. 2021 Jan 13;21:11. doi: 10.1186/s40644-021-00381-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Different uptake of ¹⁸F-FDG on PET according to the expression level of PD-L1 within tumor cells. a 80-years old male with poorly differentiated adenocarcinoma (p-T2bN0M0); PET showed increased accumulation of ¹⁸F-FDG (white arrow) with SUV_max of 10.2 in the primary site corresponding to CT (white arrowhead). Immunohistochamical finding of this resected primary lesion exhibited high expression of PD-L1 with more than 50%. b 63-years old male with squamous cell carcinoma (p-T1bN0M0); moderate uptake of ¹⁸F-FDG (white arrow) with SUV_max of 5.6 was observed in the primary site corresponding to CT (white arrowhead). Moderate expression of PD-L1 with 1–49% was assessed in this resected primary site by immunohistochemistry. c 68-years female with well differentiated adenocarcinoma (p-T1bN0M0); PET revealed weak accumulation of ¹⁸F-FDG (white arrow) with SUV_max of 2.4 in the primary site corresponding to CT (white arrowhead). Immunohistochamical finding of this resected primary lesion displayed no expression of PD-L1 with less than 1%