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. 2021 Jan 12;22:22. doi: 10.1186/s12859-020-03929-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Comparisons between the trends of scores and significance for dpGSEA and the CMAP native and gene2drug approach. Each point within each plot represents a screened drug’s significance and score within an equivalent run for dpGSEA (plots a, b), CMAP native (plot c), and gene2drug (plot d). Screened drugs that pass a designated FDR significance threshold (0.05) are shown in red, and screened drugs highlighted in green show statistically significant findings unique to dpGSEA’s novel TCS. Total number of screened drugs within specific significance thresholds are also shown, and it should be noted that the number passing FDR α = 0.05 using the GSEA-defined FDR threshold (plot a, b) is 121 while those that pass the BH defined threshold are 3 and 0 for CMAP and gene2drug, respectively (plot c, d)