Table 2.
A rank-ordered list of the most statistically significant ES for drugs found when performing an enrichment for INR vs. IR Treg cells using top 50 p value rank proto-matrix (derived from LINCs)
| Drug | NES | ES p value | NTCS | TCS p value | Gene |
|---|---|---|---|---|---|
| bendamustine_HT29 | 3.13 | < 0.001 | 0.88 | 0.359 | TMEM106B, TMEM135, ELOVL6, KCNJ2, LSM6, TMEM126B, TGIF1, TXNDC9, MAPKAPK5 |
| oseltamivir-carboxylate_MCF7 | 3.12 | < 0.001 | 0.97 | 0.150 | RDH11, ETS1, YAF2, UBE4B, SFPQ, FRYL |
| medrysone_PC3 | 3.00 | < 0.001 | 0.92 | 0.267 | FAM13B, BMPR1A, MYO7A, CAST, H2AFV, RABL6 |
| luliconazole_HT29 | 3.42 | < 0.001 | 0.90 | 0.314 | RBM7, TMED7, NXT2, ATMIN, SUB1, NPTN, WASF2, CEP135, RDH14 |
| doxofylline_MCF7 | 3.43 | < 0.001 | 0.88 | 0.347 | SUCLG2, TM9SF3, BRD7, RPL36, APPBP2, MRPL33, ARL5A, TGFB3, LRRC15, HSP90B1, RPS25 |
| ibutilide_HELA | 3.23 | 0.001 | 0.91 | 0.294 | EDEM3, RAD21, RAB35, ADGRF1, CBX1, SCN2B |
| cevimeline_HA1E | 2.88 | 0.001 | 0.84 | 0.421 | EDEM3, UBE4B, CTSD, LRRC15, ID2, SRSF11, TRIM21, NUCKS1, PARP1, SH2D3A |
| chrysin_HA1E | 3.10 | 0.001 | 0.86 | 0.386 | EDEM3, PBRM1, GANAB, MRPL33, LARP4, NKRF, BMI1, NOC3L, CORO2A |
| amtolmetin-guacil_MCF7 | 2.81 | 0.001 | 0.88 | 0.330 | EDEM3, ASB13, SCAMP1, TRAPPC6A, EP300, MFSD6, AZIN1, CIAO1 |
| triamterene_HT29 | 3.04 | 0.001 | 0.95 | 0.188 | TMEM106B, UGDH, ELOVL5, BNIP1, ZBTB11, PIH1D1 |
Both normalized ES and normalized TCS along with their respective statistical significance are shown. The leading-edge genes are also displayed, indicating genes driving the enrichment scores. Note that the highest ranked result, oseltamivir-carboxylate, suppresses influenza virions production modulates human sialidases, known for mitochondrial involvement and regulation of cell apoptosis