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. 2021 Jan 13;14:7. doi: 10.1186/s13072-020-00380-6

Fig. 1.

Fig. 1

CNFs and PNFs are epigenetically distinct tumor types. a Clinical presentation of a CNF with H/E stain (20X/100X magnification shown); versus b PNF resected from deep shoulder location (T2-weighted MRI image; H/E 20X/100X shown). c Principal component analysis of RNAseq expression data comparing CNFs (purple) and PNFs (green) neurofibromas. d Copy number analysis of CNFs versus PNFs. e Unsupervised hierarchical cluster analysis of methylation probesets (i.e., beta-values) demonstrating unique CNF and PNF methylation profiles