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. 2021 Jan 13;14:7. doi: 10.1186/s13072-020-00380-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Chromatin architecture analysis reveals distinct structural and site-specific methylation events. a Genome-wide chromatin compartment calling (X-chromosome excluded) comparing CNFs to PNFs. b DMR analysis of overlapping promoter and enhancer space between CNFs and PNFs. Top 100 significant DMR sites shown. c Chromatin compartment concordance is depicted as the fraction of CNF and PNF compartment overlap at 100 kb resolution. d Chromosome 17 was the most differentially methylated chromosome. Chromosome-specific analysis of promoter and enhancer space shown. Red bar indicates position of the NF1 gene. e Chromatin structural analysis demonstrating the distribution of DMR calls in topographic CpG categories (i.e., shelves, shores, islands, promoters and enhancers)