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. 2021 Jan 13;11:18. doi: 10.1186/s13578-021-00529-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — a Structure of the four MiT family members. AD, acidic domain; bHLH, basic helix-loop-helix; LZ, leucine zipper; Ser, serine-rich region; Gln, glutamine-rich region; Pro, proline-rich segment; Pro + Arg, proline- and arginine-rich region

(adapted from [1112, 186]. b Different MiTF isoforms. Each isoform is driven by its own promoter and has a partially unique exon, while exons from 2 through 9 are common in all isoforms. c MITF mutations found in melanoma (blue, on top) and in pigment deficiency syndromes (WS2A and TS patients, red, bottom) (adapted from [37]