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. 2021 Jan 13;26:7. doi: 10.1186/s40001-021-00479-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Immunohistochemical results of CRF in the central nervous system of the two groups. The brown particles refer to the expression of CRF. a The expression of CRF in the spinal cord in the control group. b The expression of CRF in the spinal cord in the model group. c The expression of CRF in the hypothalamus in the control group. d The expression of CRF in the hypothalamus in the model group. e The expression of CRF in the diaphragmatic surface of the third ventricle of the cerebrum in the control group. f The expression of CRF in the diaphragmatic surface of the third ventricle of the cerebrum in the model group